PUBLICATIONS

Long range mutual activation establishes Rho and Rac polarity during cell migration

De Belly H. , Gallén AF, Strickland E, Estrada DC, Zager PJ, Burkhardt JK, Turlier H, Weiner OD (2024). bioRxiv doi.org/10.1101/2024.10.01.616161.

YAP charge patterning mediates signal integration through transcriptional co-condensates

Meyer K, Yserentant K, Cheloor-Kovilakam R, Ruff M, Chung CI, Shu X, Huang B, Weiner OD (2024). bioRxiv doi.org/10.1101/2024.08.10.607443.

The WAVE complexes forms linear arrays at negative membrane curvature to instruct lamellipodia formation

Wu M, Marchando P, Meyer K, Tang Z, Woolfson DN, Weiner OD (2024). bioRxiv doi.org/10.1101/2024.07.08.600855.

Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells

Winer BY#, Settle A, Jeronimo C, Lazarov T, Tipping M, Saoi M, Sawh H, Geissmann F, Cross J, Zhou T, Cyster JG#, Weiner OD#, Huse M#. Science Immunology, 9:eadl2388 (2024). (#corresponding author)

Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming

Strickland E, Pan D, Godfrey C, Kim JS, Hopke A, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner OD. Dev. Cell, doi.org/10.1016/j.devcel.2024.06.003 (2024).

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Neutrophils actively swell to potentiate rapid migration

Nagy TL, Strickland E, Weiner OD. eLife, 12:RP90551 (2024).

eLife Insight

Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid guidance

Town JP, Weiner OD. PLoS Biology, 21:e3002307 (2023).

Optogenetic control of Yap reveals a dynamic communication code for stem cell fate and proliferation

Meyer, K., Lammers, N.C., Bugaj, L.J., Garcia, H.G., and Weiner, O.D. Nature Communications (2023).

Cell protrusions and contractions generate long-range membrane tension propagation

De Belly H, Yan S, Borja da Rocha H, Ichbiah S, Town JP, Zager PJ, Estrada DC, Meyer K, Turlier H, Bustamante C, Weiner OD. Cell, 14: 3049-3061. (2023).

Cell Preview

Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration

Saha, S., Town, J.P., and Weiner, O.D. Mol. Biol. Cell, 34: ar35. (2023).

Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation

Britain, D.M., Town, J.P., and Weiner, O.D. eLife (2022).

WASP links substrate topology and cell polarity to guide neutrophil migration

Brunetti RM, Kockelkoren G, Raghavan P, Bell GRR, Britain D, Puri N, Collins SR, Leonetti MD, Stamou D, Weiner OD. J. Cell Biol., 221: e202104046. (2022).

The WAVE complex associates with sites of saddle membrane curvature

Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett P, Marchuk K, Tran NHT, Krummel MF, Stamou D, Weiner OD. J Cell Biol., 220: e202003086 (2021).

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.

Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz- Muñoz A, Weiner OD. PLoS Biology, 17: e3000457 (2019).

Light-based tuning of ligand half-life supports kinetic proofreading model of T cell activation.

Tischer D, Weiner OD. eLife, 8: 42498 (2019).

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Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity.

Alexander JM, Guan J, Huang B, Lomvardas S, Weiner OD. eLife, 8: 41769 (2019).

Multiple sources of signal amplification within the B cell Ras/MAPK pathway.

Mclaurin J, Weiner OD. Mol. Biol. Cell, 30: 1610-1620 (2019).

A size-invariant bud-duration timer enables robustness in yeast cell size control.

Allard CAH, Decker F, Weiner OD#, Toettcher JE#, Graziano BR#. PLoS One, 13: e0209301 (2018). (#corresponding author)

Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.

Liu Z, Woo S, Weiner OD. Development, 145: dev163535 (2018).

Joining forces: crosstalk between biochemical signaling and physical forces orchestrates cell polarity and dynamics.

Saha S, Nagy TL, Weiner OD. Philos Trans R Soc Lond B Biol Sci, 373: rstb.2017.0145 (2018).

Chick cranial neural crest cells use progressive polarity refinement, no contact inhibition, to guide their motion.

Genuth MA, Allen CDC, Mikawa T, Weiner OD. Dev Biol., 444: S252-S261. (2018).

Clathrin assembly defines the onset and geometry of cortical patterning.

Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Dev. Cell, 43: 507-21 (2017).

A module for Rac temporal signal integration revealed with optogenetics.

Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD. J. Cell Biol., 216: 2515-2531 (2017).

TAEL: a zebrafish-optimized gene expression system with fine spatial and temporal control

Reade A, Motta-Mena LB, Stainier DY, Weiner OD#, Woo S#. Development, 144: 345-355 (2017). (#corresponding author)

Membrane tension acts through PLD2 and mTORC2 to constrain actin assembly during neutrophil migration.

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. PLoS Biology, 14: e1002474 (2016).

GB regulates coupling between actin oscillators for cell polarity and directed migration.

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. PLoS Biology, 14: e1002381 (2016).

Reversible optogenetic control of subcellular protein localization in a live vertebrate embryo.

Buckley CE, Moore RE, Reade A, Goldberg A, Weiner OD#, Clarke JDW#. Developmental Cell, 36: 117-26 (2016). (#corresponding author)

Positioning the cleavage furrow: all you need is Rho.

Liu Z, Weiner OD. Journal of Cell Biology, 6: 605-607 (2016).

Cell migration: recoiling from an embrace.

Genuth MA, Weiner OD. Current Biology, 25: R566-568 (2015).

Probing yeast polarity with acute, reversible, optogenetic inhibition of protein function.

Jost AP, Weiner OD. ACS Synthetic Biology, 4: 1077-85 (2015).

Homer3 regulates the establishment of neutrophil polarity.

Wu J, Pipathsouk A, Kizer-Gunnink A, Fusetti F, Alkema W, Liu S, ALtschuler SJ, Wu L, Kortholt A, Weiner OD.
Molecular Biology of the Cell, 26: 1629-39 (2015).

Illuminating cell signaling with optogenetic tools.

Tischer D, Weiner OD.
Nature Reviews Molecular and Cellular Biology, 15: 551-8 (2014).

Self-organization of protrusions and polarity during eukaryotic chemotaxis.

Graziano BR, Weiner OD.
Current Opinion in Cell Biology, 30: 60-67 (2014).

How to understand and outwit adaptation.

Hoeller O, Gong D, Weiner OD.
Developmental Cell, 28: 607-616 (2014).

How should we be selecting our graduate students?

Weiner OD.
Molecular Biology of the Cell, 25:429-30 (2014).

A versatile optogenetic gene expression system with rapid activation/deactivation kinetics.

Motta-Mena LB, Reade AR, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH.
Nature Chemical Biology, 10:196-202 (2014).

Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module.

Toettcher JE, Weiner OD#, Lim WA#.
Cell, 155: 1422-1434 (2013). (#corresponding author)

Editor’s Choice, Science Signaling
Recommended by Faculty of 1000

The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration.

Parent A, Weiner OD.
Current Opinion in Cell Biology, 25: 523-5 (2013).

Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils.

Dandekar SN, Park J, Peng GE, Onuffer J, Lim WA, Weiner OD.
Philosophical Transactions of the Royal Society B, 368: 20130008 (2013).

Different PI3K isoforms orchestrate different phases of macropinocytosis in Dictyostelium.

Hoeller O, Bolourani P, Stephens LR, Hawkins PT, Weiner OD, Kay RR, Weeks G.
Journal of Cell Science, 126: 4296-307 (2013).

A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast.

Yang X, Jost AP, Weiner OD#, Tang C#.
Molecular Biology of the Cell, 24: 2419-30 (2013). (#corresponding author)

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Houk A, Jilkine S, Mejean CO, Boltyanskiy R, Dufresne ER, Agenent S, Altschuler SJ, Wu LF, Weiner OD.
Cell, 148: 175-188 (2012).

Video Abstract
Preview in Developmental Cell
Dispatch in Current Biology
Featured Article in Cell Migration Gateway
Recommended by Faculty of 1000

Network crosstalk dynamically changes during neutrophil polarization.

Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF.
Cell, 149: 1073-1083 (2012).

Use the force: membrane tension as an organizer of cell shape and movement.

Diz-Muñoz A, Fletcher DA, Weiner OD
Trends in Cell Biology, 23: 47-53 (2012).

Diffusion, capture, and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells with single-molecule imaging.

Millius A, Watanabe N, Weiner OD.
Journal of Cell Science, 125: 1165-1176 (2012).

Nodal signaling regulates endodermal cell motlity and actin dynamics via Rac1 and Prex1.

Woo S, Housley MP, Weiner OD, Stainier DY.
Journal of Cell Biology, 198: 941-952 (2012).

Light-based feedback for controlling intracellular signaling dynamics.

Toettcher JE, Gong D, Lim WA, Weiner OD.
Nature Methods, 8: 837-9 (2011).

A pharmacological cocktail for arresting actin dynamics in living cells.

Peng GE, Wilson SR, Weiner OD.
Molecular Biology of the Cell, 22: 3986-94 (2011).

Light control of plasma membrane recruitment using the Phy--PIF system.

Toettcher JE, Gong D, Lim WA, Weiner OD.
Methods in Enzymology, 497: 409-23 (2011).

The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

Toettcher JE, Voigt CA, Weiner OD, Lim WA.
Nature Methods, 8: 35-8 (2011).

Sequence-dependent sorting of recycling proteins by actin- stabilized endosomal microdomains.

Puthenveedu MA, Lauffer B, Temkin P, Carlton P, Thorn K, Sedat J, Taunton J, Weiner OD, Parton RG, von Zastrow M.
Cell, 143: 761-773 (2010).

Compete globally, bud locally.

Houk AR, Millius A, Weiner OD.
Cell, 139: 656-658 (2009).

Spatiotemporal control of cell signaling using a light-switchable protein interaction.

Levskaya A, Weiner OD, Lim WA, Voigt CA.
Nature, 461: 997-1001 (2009).

Scientist Top 10 Innovation for 2009
Science Signaling Breakthrough of the Year 2009
Recommended by Faculty of 1000

Cell stimulation with optically manipulated microsources.

Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER.
Nature Methods, 6: 905-909 (2009).

Neutrophils establish rapid and robust Scar/WAVE complex polarity in an actin-dependent fashion.

Millius A*, Dandekar SN*, Houk AR*, Weiner OD.
Current Biology, 19(3): 253-259 (2009). (*equal contribution)

Manipulation of neutrophil-like HL-60 cells for the study of directed migration.

Millius A, Weiner OD.
Methods in Molecular Biology, 591: 147-58 (2009).

An actin-based wave generator organizes cell motility.

Weiner OD#, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW#.
PLoS Biology, 5(9): e221 (2007). (#corresponding author)

Hem-1 complexes regulate multiple polarity effectors at the leading edge of migrating neutrophils.

Weiner OD* , Rentel MC*, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.
PLoS Biology, 4(2): e38 (2006). (*equal contribution)

A PI(3,4,5)P3/ Rho GTPase positive feedback loop regulates neutrophil polarity.

Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR.
Nature Cell Biology, 4: 509-513 (2002).

Cell polarity: a chemical compass.

Bourne HR, Weiner OD.
Nature, 419: 21 (2002).

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass.

Weiner OD.
Current Opinion in Cell Biology, 14: 196-202 (2002).

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

Servant, G*, Weiner OD*, Herzmark P, Bhalla T, Sedat JW, Bourne HR.
Science, 287: 1037-1040 (2000). (*equal contribution)

Spatial control of actin polymerization during neutrophil chemotaxis.

Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.
Nature Cell Biology, 1: 75-81 (1999).